Constantine A. Stratakis is internationally recognized for his research, mentorship, and leadership. Dr. Stratakis has been extremely successful in using genome-wide tools to

identify most of the genes known to be responsible for the formation of adrenocortical tumors (ACT) and pituitary adenomas (PA). His laboratory has identified the genetic defects responsible for Carney complex, Carney Triad, the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome), and described new entities such as X-LAG (X-linked acrogigantism) and 3-PAs (the “3 Ps” association of paragangliomas, pheochromocytomas, and PA). It was his identification in 2000 of the protein kinase A (PKA) regulatory subunit type 1A (PRKAR1A) as the gene responsible for Carney complex that led to the identification of the PRKACA gene as the most commonly mutated gene in adrenal tumors. Dr. Stratakis described novel genes, such as GPR101 in gigantism, and succinate dehydrogenase (SDH) defects in a variety of tumors, including a disease that bears his name, and led the efforts to demonstrate that many gastric stromal sarcomas (GIST) arise due to SDH deficiency. He is the author of more than 800 publications; his work has been cited >48,000 times; and he has served in key editorial roles at leading journals, including Deputy Editor of the *Journal of Clinical Endocrinology and Metabolism* (2010–2015) and Co-Editor of *Hormone & Metabolic Research* and *Molecular & Cellular Endocrinology* (2016–present). Dr. Stratakis received the 1999 Award for Excellence in Published Clinical Research and the 2009 Ernst Oppenheimer Award, both from the Endocrine Society, as well as the 2019 Dale Medal from the Society for Endocrinology and many other honors. He is a visiting professor at academic institutions around the world and has received two honorary degrees from the Universities of Liège and Athens, respectively. As a mentor, Dr. Stratakis has trained more than 200 students, residents, pre-doctoral and post-doctoral fellows, and clinical fellows, and has received numerous awards for his teaching. He is widely recognized for his leadership; he served as President of the Society for Pediatric Research (SPR) from 2018 to 2019 and as Scientific Director at the National Institute of Child Health and Human Development (NICHD), part of the National Institutes of Health (NIH), Scientific Director from 2009 to 2020, where he oversaw one of the largest intramural research programs at the NIH, employing more than 1,200 staff members and managing an annual budget of nearly $200 million. Dr. Stratakis was recently selected to serve as the (founding) Executive Director of a new research institute in Athens, Greece—a position he assumed on March 1, 2021—along with his appointment as Research Director at FORTH, also in Greece (www.forth.gr).